Sodium Iodide → 1-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chlorobenzimidazole-2-thion-1-yl)-piperidine

HRID 2417800

반응식

HRID 2417800 반응식
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:4]1.[Cl:13][C:14]1[CH:29]=[CH:28][C:17]2[N:18]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[C:19](=[S:21])[NH:20][C:16]=2[CH:15]=1.C(N(CC)CC)C.[I-].[Na+]>CN(C)C=O>[O:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:4][CH:3]1[CH2:2][N:25]1[CH2:24][CH2:23][CH:22]([N:18]2[C:17]3[CH:28]=[CH:29][C:14]([Cl:13])=[CH:15][C:16]=3[NH:20][C:19]2=[S:21])[CH2:27][CH2:26]1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 8471TriethylamineHCID 983332-Bromomethyl-1,4-benzodioxaneHCID 30200065-Chloro-1,3-dihydro-1-(4-piperidinyl)-1H-benzimidazole-2-thione

생성물 1

HCID 130844301-[(Benzo-1,4-dioxan-2-yl)-methyl]-4-(5-chlorobenzimidazole-2-thion-1-yl)-piperidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2.3 g of 2-bromomethyl-1,4-benzodioxane, 2.35 g of 4-(5-chlorobenzimidazole-2-thion-1-yl)-piperidine, 1.4 ml of triethylamine and 0.3 g of sodium iodide were warmed at 60° C. in 25 ml of anhydrous dimethylformamide for 60 hours, and the mixture was then poured onto ice-water. The precipitate which had separated out was filtered off with suction, washed with water and dried.

후처리

  1. additionthe mixture was then poured onto ice-water
  2. customThe precipitate which had separated out
  3. filtrationwas filtered off with suction
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b618b5938727444287017692b0ce41ed
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04470989

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