Dimethylformamide → 3-((5-Nitrobenzothiazol-2-yl)amino)propanol

HRID 2417911

반응식

HRID 2417911 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])=[S:13].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]2[S:13][C:12]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])=[N:11][C:3]=2[CH:4]=1)([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 30187341-(2-Chloro-5-nitrophenyl)-3-(3-hydroxypropyl)thiourea

생성물 1

HCID 30187353-((5-Nitrobenzothiazol-2-yl)amino)propanol수율 72.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 21 parts of N-(2-chloro-5-nitrophenyl)-N'-(3-hydroxypropyl)thiourea, 10 parts of potassium carbonate and 180 parts of N,N-dimethylformamide is stirred and refluxed for 30 minutes. After cooling, 300 parts of water are added and the product is allowed to crystallize. It is filtered off and washed with water, yielding 13.3 parts (72.2%) of 3-[(5-nitro-2-benzothiazolyl)amino]-1-propanol; mp. 140°-144° C.

후처리

  1. temperaturerefluxed for 30 minutes
  2. temperatureAfter cooling
  3. customto crystallize
  4. filtrationIt is filtered off
  5. washwashed with water

출처 및 근거

ORD 기록
ord-743183d9e5e54f24a5d59264d91e52a9
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04471117

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