HCID 20446928, 화합물 → 4-[5-(1-Methylethyl)aminopentoxy]phenol

HRID 2417995노트

반응식

HRID 2417995 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2C=[C:20]([NH:22][CH:23]([CH3:25])[CH3:24])[CH:19]=[CH:18][CH:17]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[CH3:25][CH:23]([NH:22][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1)[CH3:24]

참가 물질

5

반응물 2

HCID 20446928HCID 20446928, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 133384884-[5-(1-Methylethyl)aminopentoxy]phenol수율 76.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

A solution of 1-benzyloxy-4-[5-(1-methylethyl)aminophenoxy]benzene (24 g) in acetic acid (250 ml) was hydrogenated over 1 g 10% palladium on carbon. After shaking for 0.5 hours at room temperature, the theoretical amount of hydrogen was taken up. The solvent was removed by distillation in vacuo and the residue dissolved in water. The solution was basified with saturated sodium bicarbonate solution and the product was recovered by filtration to give 13.0 g (75%) of 4-[5-(1-methylethyl)aminopentoxy]phenol, mp 95°-99° (95.7% pure by gas chromatography). Mass spectrum was compatible with the expected product.

후처리

  1. customThe solvent was removed by distillation in vacuo
  2. dissolutionthe residue dissolved in water
  3. filtrationthe product was recovered by filtration

출처 및 근거

ORD 기록
ord-dd80e40835864255a0bab407d7f2a48c
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04471116

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