Isopropylamine → 4-[3-(1-Methylethyl)aminopropyl]phenol

HRID 2417997노트

반응식

HRID 2417997 반응식
[CH3:1][CH:2]([NH:4]CCC1C=CC(O)=CC=1)[CH3:3].Br[CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1.C(N)(C)C>>[CH3:1][CH:2]([NH:4][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)[CH3:3]

참가 물질

4

반응물 3

HCID 6363IsopropylamineHCID 4175994-[2-(1-Methylethyl)aminoethyl]phenolHCID 148170364-(3-Bromopropyl)phenol

생성물 1

HCID 204469574-[3-(1-Methylethyl)aminopropyl]phenol수율 97.9%

실험 절차

Under the conditions outlined above for the preparation of 4-[2-(1-methylethyl)aminoethyl]phenol, 4-(3-bromopropyl)phenol was reacted with isopropylamine. The crude product was distilled in a Kugelrohr apparatus (150°; 1 mm) and the distillate was crystallized from ether to give 4-[3-(1-methylethyl)aminopropyl]phenol (97.9% pure by gas chromatography).

후처리

  1. distillationThe crude product was distilled in a Kugelrohr apparatus (150°; 1 mm)
  2. customthe distillate was crystallized from ether

출처 및 근거

ORD 기록
ord-dd2f28a8c0d1483faea80e8d534fd750
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04471116

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