Propylene Chlorohydrin → 2-Chloropropyl 3-oxobutanoate

HRID 2418254

반응식

HRID 2418254 반응식
C([O-])(=O)C.[Na+].[Cl:6][CH:7]([CH3:10])[CH2:8][OH:9].[CH2:11]=[C:12]1[O:16][C:14](=[O:15])[CH2:13]1>>[C:14]([O:9][CH2:8][CH:7]([Cl:6])[CH3:10])(=[O:15])[CH2:13][C:12]([CH3:11])=[O:16]

참가 물질

4

반응물 3

HCID 6566Propylene ChlorohydrinHCID 12661DiketeneHCID 517045Sodium Acetate

생성물 1

HCID 132313652-Chloropropyl 3-oxobutanoate수율 69.2%

실험 절차

0.7 g of sodium acetate was added to 7.5 g of 2-chloropropanol, to which 7.4 g of diketene was added dropwise with stirring while the reaction temperature was maintained at 40°-50° C. The reaction mixture was stirred at room temperature for an additional 2 hours and then worked up in the manner described in Referential Example 4. The resulting crude product was purified by distillation to obtain 9.8 g of 2-chloropropyl acetoacetate.

후처리

  1. additionwas added dropwise
  2. temperaturewas maintained at 40°-50° C
  3. stirringThe reaction mixture was stirred at room temperature for an additional 2 hours
  4. distillationThe resulting crude product was purified by distillation

출처 및 근거

ORD 기록
ord-871991d30cb346dc9724af0ddef45cb8
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04472411

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