Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → (4-Bromo-3-isopropyl-phenoxy)-triisopropyl-silane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Triisopropylsilyl chloride | HCID 139400 | — |
| 반응물 | 4-Bromo-3-isopropylphenol | HCID 22568801 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (4-Bromo-3-isopropyl-phenoxy)-triisopropyl-silane | HCID 22568963 | — |
반응 단계
To a solution of 4-bromo-3-isopropylphenol (880.0 mg, 4.09 mmols) and imidazole (417.0 mg, 6.13 mmols) in 10 mL DMF was added chloro-triisopropylsilane (946.0 mg, 4.90 mmols). After stirring overnight at room temperature the solution was diluted with H2O and extracted with EtOAc. The combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound, 1.30 g (92%), was isolated by column chromatography (1-2% EtOAc—hexanes) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855512B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-74eafc2aed6346979943ddb876bec676 |
| 출처 메모 | uspto-grants-2005_02 |