Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HDTrp-Leu-MetNH2 trifluoroacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | BocDTrp-Leu-MetNH2 | HCID 131713756 | — |
| 용매 | Ethyl methyl sulfide | HCID 12230 | — |
| 용매 | 1,1-Ethanedithiol | HCID 33645 | — |
| 생성물 | HDTrp-Leu-MetNH2 trifluoroacetate | HCID 131713755 | 23% |
반응 단계
Condensation of BocDTrpOPFP (8.60 g.) and HLeu-MetNH2 hydrochloride salt (Example 1, 5.44 g.) by the activated ester method gave BocDTrp-Leu-MetNH2 in 67% yield. De-t-butoxycarbonylation of BocDTrp-Leu-MetNH2 (6.69 g.) using trifluoroacetic acid in methyl ethyl sulfide and ethanedithiol gave HDTrp-Leu-MetNH2 trifluoroacetate salt in 23% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04472305 |
| 출처 데이터셋 | uspto-grants-1984_09 |
| ORD ID | ord-61fdc32b2888445d9cfb55f8896090df |
| 출처 메모 | uspto-grants-1984_09 |