Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HPro-DTrp-Gly-DTrp-Leu-MetNH2
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | BocPro-DTrp-Gly-DTrp-Leu-MetNH2 | HCID 131713803 | — |
| 용매 | Ethyl methyl sulfide | HCID 12230 | — |
| 용매 | 1,1-Ethanedithiol | HCID 33645 | — |
| 생성물 | HPro-DTrp-Gly-DTrp-Leu-MetNH2 | HCID 131713805 | — |
반응 단계
Condensation of BocPro-DTrp-GlyOH (1.00 g.) and HDTrp-Leu-MetNH2 trifluoroacetate salt (1.10 g.) using dicyclohexylcarbodiimide and N-hydroxysuccinimide gave BocPro-DTrp-Gly-DTrp-Leu-MetNH2 in 36% yield. De-t-butoxycarbonylation of BocPro-DTrp-Gly-DTrp-Leu-MetNH2 (0.68 g.) using trifluoroacetic acid in methyl ethyl sulfide and ethanedithiol gave HPro-DTrp-Gly-DTrp-Leu-MetNH2, which was isolated as the amorphous white solid phosphate (2:3) salt in 59% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04472305 |
| 출처 데이터셋 | uspto-grants-1984_09 |
| ORD ID | ord-0d05d463cff64ad182933ec8c9a54182 |
| 출처 메모 | uspto-grants-1984_09 |