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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 241862생성일: 2026년 10월 27일

3-Amino-3-[6-(trifluoromethyl)pyridin-3-yl]propan-1-ol → (R)-3-amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol

https://huagongshe.com/reaction/241862

반응식

참여 물질

역할이름HCID투입량
반응물3-Amino-3-[6-(trifluoromethyl)pyridin-3-yl]propan-1-olHCID 58103588—
용매Ethanol hexaneHCID 21879635—
생성물(R)-3-amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-olHCID 58103584—
생성물(s)-3-Amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-olHCID 58103598—

반응 단계

Racemic 3-amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol (1.10 g, 5.00 mmol) was resolved by chiral HPLC (conditions: CHIRALPAK AD-H column, 20×250 mm, hexane/EtOH [88:12] at 20 mL/min, UV at 230 nm) to give (S)-3-amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol and (R)-3-amino-3-(6-(trifluoromethyl)pyridin-3-yl)propan-1-ol. Analytical chiral HPLC: CHIRALPAK AD-H column, 250×4.6 mm, hexane/EtOH [90:10] at 1.0 mL/min, UV at 230 nm); retention time for (S)-isomer: 18.68 min (>99% ee); retention time for (R)-isomer: 23.56 min (>99% ee).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08653091B2
출처 데이터셋uspto-grants-2014_02
ORD IDord-cd47b67b95c84ec29555b3691fde0ac0
출처 메모uspto-grants-2014_02