Acetophenone → Ethyl 2-(2-Butyl)-3-hydroxy-3-methyl-3-phenylpropionate

HRID 2418631

반응식

HRID 2418631 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH3:10][CH:11]([CH2:18][CH3:19])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH3:10][CH:11]([CH:12]([C:1]([OH:3])([CH3:2])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:18][CH3:19]

참가 물질

3

반응물 2

HCID 7410AcetophenoneHCID 560255Ethyl 3-methylpentanoate

생성물 1

HCID 13742288Ethyl 2-(2-Butyl)-3-hydroxy-3-methyl-3-phenylpropionate수율 36%

실험 절차

The reaction of acetophenone (12 grams, 0.1 mole) with the enolate of ethyl 3-methylvalerate (14.4 grams, 0.1 mole) is carried out in the manner described in Example I. Distillation yields 9.5 grams (36%) of the pure product, b.p. 75°-80° C. (air bath temperature) at 0.05 mm Hg. I.R., N.M.R. and M.S. data confirm the above structure.

후처리

  1. distillationDistillation

출처 및 근거

ORD 기록
ord-b8b9398871194129b91d33b382191fdd
출처 데이터셋
uspto-grants-1984_09
특허 번호
US04473085

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