4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 2-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester

HRID 2418903

반응식

HRID 2418903 반응식
CC1(C)OB(c2ccncc2)OC1(C)C.O=S(O)C(F)(F)F.[Zn]>CC(C)(C)OO.ClCCl.O>CC1(C)OB(c2ccnc(C(F)(F)F)c2)OC1(C)C.N#Cc1ncc(C(F)(F)F)cn1

참가 물질

7

반응물 2

HCID 27346484-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 89601280CID 89601280

생성물 2

HCID 457857082-(Trifluoromethyl)pyridine-4-boronic acid, pinacol ester수율 50%HCID 534183285-(Trifluoromethyl)pyrimidine-2-carbonitrile수율 31%

시약·촉매·용매 3

HCID 6410tert-Butyl hydroperoxide시약HCID 962Water용매HCID 6344Dichloromethane용매

반응 조건

온도
50 °C

출처 및 근거

ORD 기록
ord-872cd33066aa40a991c46777b535e5b7
출처 데이터셋
Minisci dataset from Roche

연결된 노트

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