Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → 2-Amino-N-(2-chlorophenyl)-6-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | 2-Chloroaniline | HCID 7240 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 6-Methylanthranilic acid | HCID 151210 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 2-Amino-N-(2-chlorophenyl)-6-methylbenzamide | HCID 16785685 | 51% |
반응 단계
Prepared according to Procedure A using 2-amino-6-methylbenzoic acid (2.5 g, 16.5 mmol) and SOCl2 (3.0 mL, 41.3 mmol) in benzene (75 mL), followed by 2-chloroaniline (3.5 mL, 33.0 mmol) and CHCl3 (75 mL). The product was chromatographed in CH2Cl2 to provide 2.19 g of a brown oil (51%). 1H NMR (CDCl3) δ: 8.58 (d, J=8.1 Hz, 1H); 7.99 (br s, 1H); 7.40 (dd, J=1.4, 8.0 Hz, 1H); 7.34 (t, J=7.7 Hz, 1H); 7.11 (t, J=7.8 Hz, 1H); 7.09 (dt, J=1.5, 7.7 Hz, 1H); 6.64 (d, J=7.5 Hz, 1H); 6.59 (d, J=8.1 Hz, 1H); 4.29 (br s, 2H); 2.45 (s, 3H). MS (ES): m/z 283.0 (M+22).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653077B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-1706074f86fa469996e85fdf3d4a0dc0 |
| 출처 메모 | uspto-grants-2014_02 |