Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-Chloronicotinic acid | HCID 76258 | — |
| 반응물 | Methyl 6-amino-1,3-benzodioxole-5-carboxylate | HCID 290838 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2,3-methylenedioxy-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid | HCID 20316839 | — |
반응 단계
A mixture of 2.00g (10.4 mmol) of methyl 2-amino-4,5-methylenedioxybenzoate, 1.67g (10.4 mmol) of 2-chloronicotinic acid and 50mg of KI was heated at 170° for 1 hour. The fusion or melt gradually solidified to an orange cake. The solid material was heated in boiling methanol (250 ml) and then filtered to yield 1.60g of crude product, mp. 273°-280° dec. The analytical sample was obtained by recrystallization from DMF, mp. 300°-304° dec.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04104389 |
| 출처 데이터셋 | uspto-grants-1978_08 |
| ORD ID | ord-6c4ebe5621724a688721fa60eaf7865f |
| 출처 메모 | uspto-grants-1978_08 |