Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 2-Chloromethyl-3-(2-chlorophenyl)-5-fluoro-3H-quinazolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 2-amino-N-(2-chlorophenyl)-6-fluorobenzamide | HCID 22316568 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Chloromethyl-3-(2-chlorophenyl)-5-fluoro-3H-quinazolin-4-one | HCID 22316567 | 70.4% |
반응 단계
Prepared according to Procedure B with 1e (500 mg, 1.89 mmol) and chloroacetyl chloride (0.45 mL, 5.67 mmol) in acetic acid (10 mL). Purified by extraction from aq. K2CO3 and recrystallization from isopropanol to afford 430 mg of an off-white crystalline solid (70%). 1H NMR (CDCl3) δ: 7.76 (dt, J=5.3, 8.2 Hz, 1H); 7.56-7.65 (m, 2H); 7.47-7.56 (m, 3H); 7.16-7.25 (m, 1H); 4.35 (d, J=12 Hz, 1H), 4.07 (d, J=12 Hz, 1H). MS (ES): m/z 323.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653077B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-4926188f0c694731908c918c24a1219d |
| 출처 메모 | uspto-grants-2014_02 |