4-(2-Chloro-2-cyanoethyl)benzoic acid → 4-(2-Cyanoethyl)benzoic acid

HRID 2419195노트

반응식

HRID 2419195 반응식
Cl[CH:2]([C:13]#[N:14])[CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1>[Zn].C(O)(=O)C>[C:13]([CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:14]

참가 물질

4

반응물 1

HCID 508886404-(2-Chloro-2-cyanoethyl)benzoic acid

생성물 1

HCID 198791964-(2-Cyanoethyl)benzoic acid

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

100 parts of zinc powder are gradually added to a solution of 209.5 parts of 4-(2-chloro-2-cyanoethyl) benzoic acid in 500 parts of glacial acetic acid. The temperature rises quickly up to reflux and is maintained for approximately one hour. The solution is filtered when hot so as to eliminate the insoluble matter, then the filtrate is diluted with 1,000 parts of water and the precipitate formed is isolated. Thus 122 parts of 4-(2-cyanoethyl) benzoic acid are obtained. M.P.: 182° C.

후처리

  1. temperatureto reflux
  2. temperatureis maintained for approximately one hour
  3. filtrationThe solution is filtered when hot so as
  4. additionthe filtrate is diluted with 1,000 parts of water
  5. customthe precipitate formed
  6. customis isolated

출처 및 근거

ORD 기록
ord-6831b6236dcd41e4aa97d6b34ca2c166
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04105653

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