4'-Hydroxyacetophenone → HCID 20315614, 화합물

HRID 2419355노트

반응식

HRID 2419355 반응식
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]([O:11][CH:12]([CH3:14])[CH3:13])=[O:10].[CH3:15][C:16]([C:18]1[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=1)=[O:17]>CC(C)=O>[C:16]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:8][C:9]([O:11][CH:12]([CH3:14])[CH3:13])=[O:10])=[CH:20][CH:19]=1)(=[O:17])[CH3:15]

참가 물질

5

반응물 3

HCID 74694'-HydroxyacetophenoneHCID 11430Potassium CarbonateHCID 121593Isopropyl bromoacetate

생성물 1

HCID 20315614HCID 20315614, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Potassium carbonate (17.0g.) was added to a solution of isopropyl bromoacetate (24.0g.) and 4-hydroxyacetophenone (17.7g.) in acetone (200ml.). The mixture was heated under reflux for 24 hours, cooled and filtered. The filtrate was evaporated to an oil which was dissolved in ether (150ml.). The solution was washed with sodium bicarbonate solution (2 × 30ml.), water (2 × 30ml.), dried and evaporated. The residual oil was distilled to give isopropyl 4-acetylphenoxyacetate, I.R. peaks at 1750 and 1670 cm-1.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe filtrate was evaporated to an oil which
  6. dissolutionwas dissolved in ether (150ml.)
  7. washThe solution was washed with sodium bicarbonate solution (2 × 30ml.), water (2 × 30ml.)
  8. customdried
  9. customevaporated
  10. distillationThe residual oil was distilled

출처 및 근거

ORD 기록
ord-4623b85c58ac4ffcb1ff0d3dc1f645c1
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04105790

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