Methanol → Methyl 4-(aminoacetyl)phenoxyacetate hydrochloride

HRID 2419364노트

반응식

HRID 2419364 반응식
S(Cl)([Cl:3])=O.Cl.[NH2:6][CH2:7][C:8]([C:10]1[CH:20]=[CH:19][C:13]([O:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)=[O:9].[CH3:21]O>>[ClH:3].[NH2:6][CH2:7][C:8]([C:10]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][C:16]([O:18][CH3:21])=[O:17])=[CH:19][CH:20]=1)=[O:9]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 145369464-(Aminoacetyl)phenoxyacetic acid hydrochloride

생성물 1

HCID 20315552Methyl 4-(aminoacetyl)phenoxyacetate hydrochloride수율 62%

실험 절차

Methanol (250ml.) was stirred at -20° C. as thionyl chloride (6ml.) was added. 4-(Aminoacetyl)phenoxyacetic acid hydrochloride (5.0g) was added, and the mixture was stirred and allowed to warm to room temperature during 18 hours. The resulting solution was evaporated under reduced pressure and the residue was recrystallised from a mixture of methanol and diethyl ether to give methyl 4-(aminoacetyl)-phenoxyacetate hydrochloride, m.p. 202°-204° C. (Example 12) in 62% yield.

후처리

  1. additionwas added
  2. customThe resulting solution was evaporated under reduced pressure
  3. customthe residue was recrystallised from a mixture of methanol and diethyl ether

출처 및 근거

ORD 기록
ord-800387dbdf12442491dfbf59280641f7
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04105790

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