Styrene Oxide → 1-Aziridineethanol, alpha-phenyl-

HRID 2419534

반응식

HRID 2419534 반응식
[CH2:1]1[NH:3][CH2:2]1.[CH2:4]1[O:12][CH:5]1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[K+]>O>[C:6]1([CH:5]([OH:12])[CH2:4][N:3]2[CH2:2][CH2:1]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 7276Styrene OxideHCID 9033AziridineHCID 14797Potassium Hydroxide

생성물 1

HCID 288341-Aziridineethanol, alpha-phenyl-

시약·촉매·용매 1

HCID 962Water촉매

실험 절차

To a solution of 43.0 g. (1.0 mole) of ethyleneimine and 60.0 g. (0.5 mole) of styrene oxide is added 3 drops of water and 0.2 g. of potassium hydroxide. The mixture is heated at reflux for 11/2 hours. Distillation of the excess ethyleneimine from the crude product gives 55.6 g. (68%) of the crystalline product. Recrystallization gives pure dl-α-phenyl-1-aziridineethanol with melting point 74°-76° C.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 11/2 hours
  3. distillationDistillation of the excess ethyleneimine from the crude product
  4. customgives 55.6 g
  5. customRecrystallization

출처 및 근거

ORD 기록
ord-7f3685b9caf94002bebd8bb3eec9d5c6
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04107170

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