Cyclopropanecarbonyl chloride → HCID 20314164, 화합물
반응식
[F:1][C:2]([F:21])([F:20])[C:3]([C:16]([F:19])([F:18])[F:17])([C:5]1[CH:6]=[CH:7][C:8]2[NH:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:15]=1)[OH:4].[CH:22]1([C:25](Cl)=[O:26])[CH2:24][CH2:23]1>C1(C)C=CC=CC=1>[CH:22]1([C:25]([N:14]2[C:8]3[CH:7]=[CH:6][C:5]([C:3]([C:2]([F:1])([F:20])[F:21])([C:16]([F:19])([F:17])[F:18])[OH:4])=[CH:15][C:9]=3[CH2:10][CH2:11][CH2:12][CH2:13]2)=[O:26])[CH2:24][CH2:23]1참가 물질
4
실험 절차
To 200 ml dry toluene is added 6.3 g (0.020 mole) α,α-bis(trifluoromethyl)-2,3,4,5-tetrahydro-1H-1-benzazepine-7-methanol and 3.0 g (0.025 mole) cyclopropane carboxylic acid chloride. The solution is stirred and heated at reflux under nitrogen for sixteen hours, then cooled and evaporated at reduced pressure. The residual solid is recrystallized from chlorobutane to give 5.0 g, m.p. 165°-167°.