Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Nicotinate → Nicotinic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Nicotinate | HCID 7151 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 3-Amino-4-nitrobenzotrifluoride | HCID 223100 | — |
| 반응물 | 2-Amino-4-nitrobenzotrifluoride | HCID 2737719 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Nicotinic Acid | HCID 938 | 46.4% |
반응 단계
Add 20 ml of dioxan and 10 g of 2-trifluoromethyl-5-nitroaniline or 2-nitro-5-trifluoromethyl-aniline to 12 g of nicotinic acid methyl ester. Reflux for 60 hours; then pour the reaction mass into water. Filter the resulting solid and recrystallize several times from ethanol. 5 g of (I) or (III) are thus obtained with the same melting-point values as the products of Examples 1 and 3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04107316 |
| 출처 데이터셋 | uspto-grants-1978_08 |
| ORD ID | ord-fa18031f90554cfdad678aafad4662a9 |
| 출처 메모 | uspto-grants-1978_08 |