Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Butanol → 1-{[1-(p-Chlorophenyl)cyclopropyl]methyl}-3-(2,6-dichlorobenzylideneamino)guanidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Butanol | HCID 263 | — |
| 반응물 | [1-(4-Chlorophenyl)cyclopropyl]methanamine | HCID 4120166 | — |
| 반응물 | Methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide | HCID 178504060 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-{[1-(p-Chlorophenyl)cyclopropyl]methyl}-3-(2,6-dichlorobenzylideneamino)guanidine | HCID 178512088 | — |
반응 단계
A solution of 7.80 g. of methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide and 4.37 g. of 1-(p-chlorophenyl)cyclopropanemethylamine in 100 ml. of n-butanol and 25 ml. of water is heated at reflux for 24 hours. The solution is cooled, diluted with water to a final volume of 2 liters and allowed to stand. Filtration gives a tan solid which is dissolved in ethyl acetate and purified by silica gel column chromatography. Crystallization of the product from diethyl ether gives the desired final product as colorless crystals, m.p. 126°-128° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04107326 |
| 출처 데이터셋 | uspto-grants-1978_08 |
| ORD ID | ord-4944ab98b94743809047afb25af45334 |
| 출처 메모 | uspto-grants-1978_08 |