Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Ethyl 2-diazo-3-(2,6-difluorophenyl)-3-oxopropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Acetamidobenzenesulfonyl azide | HCID 5129185 | — |
| 반응물 | Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate | HCID 13550002 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 2-diazo-3-(2,6-difluorophenyl)-3-oxopropanoate | HCID 86681842 | — |
반응 단계
Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate (12.3 g, 53.8 mmol) and triethylamine (22.5 mL, 0.161 mol, 3.0 equiv) were dissolved in acetonitrile (160 mL) and treated with 4-acetamidobenzenesulfonyl azide. The mixture was stirred for 18 hours at ambient temperature, concentrated in vacuo and the residue was purified by silica gel chromatography (eluting with chloroform), providing the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653079B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-e0f28b7b3da446fe96e04a73dd325fa2 |
| 출처 메모 | uspto-grants-2014_02 |