Triethylamine → HCID 86681842, 화합물

HRID 241982

반응식

HRID 241982 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(N(CC)CC)C.C(NC1C=CC(S([N:37]=[N+:38]=[N-])(=O)=O)=CC=1)(=O)C>C(#N)C>[N+:37](=[C:10]([C:9]([C:3]1[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=1[F:8])=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N-:38]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 51291854-Acetamidobenzenesulfonyl azideHCID 13550002Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate

생성물 1

HCID 86681842HCID 86681842, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Ethyl 3-(2,6-difluorophenyl)-3-oxopropanoate (12.3 g, 53.8 mmol) and triethylamine (22.5 mL, 0.161 mol, 3.0 equiv) were dissolved in acetonitrile (160 mL) and treated with 4-acetamidobenzenesulfonyl azide. The mixture was stirred for 18 hours at ambient temperature, concentrated in vacuo and the residue was purified by silica gel chromatography (eluting with chloroform), providing the titled compound.

후처리

  1. concentrationconcentrated in vacuo
  2. customthe residue was purified by silica gel chromatography (eluting with chloroform)

출처 및 근거

ORD 기록
ord-e0f28b7b3da446fe96e04a73dd325fa2
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653079B2

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