L-Alanine → Leucyl-alanyl-glycyl-valine

반응식

[NH2:1][C@H:2]([C:7]([OH:9])=O)[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:10][C@H:11]([C:13]([OH:15])=O)[CH3:12].[NH2:16][C@H:17]([C:21]([OH:23])=[O:22])[CH:18]([CH3:20])[CH3:19]>>[NH2:1][C@H:2]([C:7]([NH:10][C@H:11]([C:13]([NH:1][CH2:2][C:7]([NH:16][C@H:17]([C:21]([OH:23])=[O:22])[CH:18]([CH3:20])[CH3:19])=[O:9])=[O:15])[CH3:12])=[O:9])[CH2:3][CH:4]([CH3:5])[CH3:6]

참가 물질

반응물 3

HCID 5950L-Alanine

HCID 6106L-Leucine2회

HCID 6287L-Valine

생성물 1

HCID 152207Leucyl-alanyl-glycyl-valine

실험 절차

The completed Boc-tetrapeptide resin was subjected to steps (1) and (2) to cleave the Boc group and worked up as described for (A) to yield 707 mg of peptide resin. Amino acid analysis: Gly 1.05, Ala 1.00, Val 1.12, Leu 1.05.

출처 및 근거

ORD 기록: ord-2f0d1be5949d48eea239a4bd8cbc9854
출처 데이터셋: uspto-grants-1978_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04108846

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