Thionyl Chloride → Pseudosaccharin chloride

HRID 2419998노트

반응식

HRID 2419998 반응식
[S:1]1(=[O:11])(=[O:10])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[N:2]1.S(Cl)([Cl:14])=O.O1CCOCC1>CN(C)C=O>[Cl:14][C:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1](=[O:10])(=[O:11])[N:2]=1

참가 물질

5

반응물 3

HCID 24386Thionyl Chloride2회HCID 312751,4-DioxaneHCID 130862071H-1lambda~6~,2-Benzothiazole-1,1-dione

생성물 1

HCID 64783Pseudosaccharin chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

100 g (545 mM) of benzisothiazole-1,1-dioxide 100 ml. of thionyl chloride, 4 ml. of dimethylformamide (catalyst) and 400 ml. of dioxane are refluxed overnight. Thionyl chloride (50 ml.) and dimethylformamide (1 ml.) are added to the reaction mixture which is again refluxed overnight. The reaction mixture is evaporated to dryness and the residue recrystallized from toluene to obtain 73.4 g of 3-chloro-1,2-benzisothiazole-1,1-dioxide, m.p. 140°-145°.

후처리

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue recrystallized from toluene

출처 및 근거

ORD 기록
ord-04b913fb6bf6417b9da2b894a1c6d41a
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04108860

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