Sodium Iodide → 1-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one

HRID 2420063노트

반응식

HRID 2420063 반응식
Cl/[CH:2]=[CH:3]/[C:4](=[O:17])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:15][CH2:14][CH:13]2[CH2:16][CH:10]1[CH2:11][CH2:12]2.[I-:18].[Na+]>CC(C)=O>[I:18]/[CH:2]=[CH:3]/[C:4](=[O:17])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:15][CH2:14][CH:13]2[CH2:16][CH:10]1[CH2:11][CH2:12]2

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 21325429HCID 21325429, 화합물

생성물 1

HCID 213254401-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1-E-hepten-3-one수율 88%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 3.2 g (13 mmol) of 1-chloro-7-(bicyclo[3.2.1]oct-2-yl)-1E-hepten-3-one and 7.5 g (50 mmol) of sodium iodide in 25 ml of dry acetone (distilled from potassium carbonate) was refluxed for 18 hr under nitrogen. The solvent was removed in vacuo, and the residue was taken up in 50 ml of water and then extracted three times with 30 ml portions of ether. The combined ether extracts were washed with aqueous sodium thiosulfate, dried (MgSO4) and evaporated in vacuo to yield 3.8 g (88%) of 1-iodo-7-(bicyclo[3.2.1]oct-2-yl)-1E-hepten-3-one.

후처리

  1. customThe solvent was removed in vacuo
  2. extractionextracted three times with 30 ml portions of ether
  3. washThe combined ether extracts were washed with aqueous sodium thiosulfate
  4. dry with materialdried (MgSO4)
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-337d4f4cf9e148129b9944ef855cc402
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04108892

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