2-Methylbenzenesulfonic acid → HCID 20311044, 화합물

HRID 2420186노트

반응식

HRID 2420186 반응식
[CH:1]([N:4]([CH2:9][CH:10]([O:14]CC)[O:11][CH2:12]C)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2].[C:17]1([CH3:27])[C:18](S(O)(=O)=O)=[CH:19]C=C[CH:22]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH:1]([N:4]([CH2:9][CH:10]1[O:11][CH2:12][CH:18]([CH3:19])[CH:17]([CH3:27])[CH2:22][O:14]1)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 22768137HCID 22768137, 화합물

생성물 1

HCID 20311044HCID 20311044, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-Isopropyl-N-(2,2-diethoxyethyl)-α-chloroacetamide (10 grams), 2,3-dimethylbutandiol-1,4 (4.5 grams) and trace amounts of toluenesulfonic acid are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated until no more ethanol is given off. After this time sodium carbonate (1 gram) is added to the mixture with stirring and the resulting mixture is distilled to yield the desired product N-isopropyl-N-(5,6-dimethyl-1,3-dioxepan-2-ylmethyl)-α-chloroacetamide as an oil.

후처리

  1. additionare charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. distillationthe resulting mixture is distilled

출처 및 근거

ORD 기록
ord-2f1e540daec14140b7a64f41addb4895
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04110101

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