Water → 1-(5-Methylthiophen-3-yl)ethan-1-one

HRID 2420251노트

반응식

HRID 2420251 반응식
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=O)[CH:6]=1.[CH2:10](OCC)C.C[Li].O>C(O)C>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([CH3:10])=[O:9])[CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 3283Diethyl EtherHCID 2090693-Thiophenecarboxylic acid, 5-methyl-HCID 178418348HCID 178418348, 화합물

생성물 1

HCID 212902951-(5-Methylthiophen-3-yl)ethan-1-one

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

2-Methylthiophene-4-carboxylic acid (14.2 g., 0.1 mole) prepared by the method of Shvedov et al., Khim. Geterotsikl. Soedin. 1010 (1967); Chem. Abstrs., 69, 51922j (1968) in 250 ml. of ethyl ether is cooled to -10° to 0° C. and an ethereal solution of methyl lithium (4.4 g., 0.2 mole) is added dropwise while maintaining the reaction mixture below 0° C. After stirring for 1 hour at 0° C., a solution of 4 g. of water in 100 ml. of ethanol is added cautiously and the mixture allowed to warm to room temperature. The desired product is then isolated by partitioning the reaction mixture between ether and water and evaporation of the organic extracts.

후처리

  1. temperaturewhile maintaining the reaction mixture below 0° C
  2. temperatureto warm to room temperature

출처 및 근거

ORD 기록
ord-2fc3fbe0f80e47b0b95fb786b72ffbff
출처 데이터셋
uspto-grants-1978_08
특허 번호
US04110342

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