Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethylaminopropyl chloride, hydrochloride → 3-(3-Diethylaminopropyl)-5-(indol-3-ylmethyl)hydantoin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethylaminopropyl chloride, hydrochloride | HCID 145749 | — |
| 반응물 | 5-(1h-Indol-3-ylmethyl)imidazolidine-2,4-dione | HCID 242867 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(3-Diethylaminopropyl)-5-(indol-3-ylmethyl)hydantoin | HCID 20312119 | — |
반응 단계
A mixture of 5-(indol-3-ylmethyl)hydantoin (10 g, 0.04 mole), 3-chloro-N,N-diethylpropylamine hydrochloride (8.2 g, 0.04 mole), NaOC2H5 (0.08 mole) and 500 ml of anhydrous C2H5OH was heated to reflux with stirring for 20 hours. The mixture was filtered and concentrated to dryness. The concentrate was dissolved in CHCl3, filtered and concentrated. The concentrate was crystallized and recrystallized from benzene-petroleum ether. The solid was again recrystallized from xylene and the solvated solid was dried in vacuum, yield 2.5 g, mp 90°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04110536 |
| 출처 데이터셋 | uspto-grants-1978_08 |
| ORD ID | ord-9fac1453dee7497da7051b9ae27155c3 |
| 출처 메모 | uspto-grants-1978_08 |