Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N-Dimethyl-1,3-propanediamine → 2-Ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester | HCID 162357 | — |
| 반응물 | 1-isopropyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester | HCID 428334 | — |
| 반응물 | Methanimidic acid, N-cyano-, ethyl ester | HCID 9920370 | — |
| 반응물 | ethyl N-cyanopropionimidate | HCID 10820532 | — |
| 반응물 | 5-chloro-2-ethyl-8-isopropyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine | HCID 22758508 | — |
| 반응물 | 8-ethyl-2-methylthio-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)-one | HCID 135593862 | — |
| 생성물 | 2-Ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine | HCID 22758539 | — |
반응 단계
By substituting 1-isopropyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester for the 1-ethyl-4-hydrazino-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester and 1-ethoxypropylidene cyanamide for the ethoxymethylene cyanamide in part (a) and morpholine for the 3-dimethylaminopropylamine in part (c) of the procedure of Example 1,2-ethyl-8-isopropyl-4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4-]triazolo[1,5-a]pyrimidin5(8H)-one, 5-chloro-2-ethyl-8-isopropyl-8H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidine and 2-ethyl-8-isopropyl-5-morpholino-8H-pyrazolo[4',3':5,6]pyrido[3,4e][1,2,4]triazolo[1,5-a]pyrimidine, respectively, are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04110454 |
| 출처 데이터셋 | uspto-grants-1978_08 |
| ORD ID | ord-091868ab1e7a4c828d995eeb601dc228 |
| 출처 메모 | uspto-grants-1978_08 |