Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 7-(Benzyloxy)-1-[1-(4-chloro-2-methoxyphenyl)cyclobutyl]-3,4-dihydroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | N-{2-[4-(Benzyloxy)phenyl]ethyl}-1-(4-chloro-2-methoxyphenyl)cyclobutanecarboxamide | HCID 66868466 | — |
| 생성물 | 7-(Benzyloxy)-1-[1-(4-chloro-2-methoxyphenyl)cyclobutyl]-3,4-dihydroisoquinoline | HCID 58246249 | — |
반응 단계
7-(Benzyloxy)-1-[1-(4-chloro-2-methoxyphenyl)cyclobutyl]-3,4-dihydroisoquinoline was prepared analogously to example 65 using N-{2-[4-(benzyloxy)phenyl]ethyl}-1-(4-chloro-2-methoxyphenyl)cyclobutanecarboxamide (1.1 g, 2.445 mmol) and phosphoric trichloride (3.75 g, 24.45 mmol). Yield: 65 mg (0.15 mmol, 6%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08653100B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-7868f003e6fd4ce9ac2d5051bef428d1 |
| 출처 메모 | uspto-grants-2014_02 |