Triethylamine → N-(6-chloro-5-ethylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride (1.08 g, 4.15 mmol) was placed in an oven-dried flask which was allowed to cool under nitrogen. Dichloromethane (10 mL), triethylamine (1.75 mL, 12.5 mmol), and 6-chloro-5-ethylpyridin-2-amine (4.15 mmol) were added and the reaction mixture was stirred for 16 hours. The reaction mixture was then washed with a saturated aqueous solution of sodium chloride, evaporated to near dryness, and then purified on 40 g of silica gel utilizing a gradient of 0-30% ethyl acetate in hexanes to yield N-(6-chloro-5-ethylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide (1.09 g, 69%). ESI-MS m/z calc. 380.1, found; 381.0 (M+1)+Retention time 2.24 minutes.

1. temperatureto cool under nitrogen
2. washThe reaction mixture was then washed with a saturated aqueous solution of sodium chloride
3. customevaporated
4. custompurified on 40 g of silica gel utilizing a gradient of 0-30% ethyl acetate in hexanes

ORD 기록

ord-1951f9ce6c7b4888bf1d8f167ff4d84d

출처 데이터셋

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07956052B2