Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2421029생성일: 2026년 10월 26일
p-Toluenesulfonic acid → Ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
https://huagongshe.com/reaction/2421029
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Acrylamide | HCID 6579 | — |
| 반응물 | Ethyl 4,4,5,5,5-Pentafluoro-3-oxovalerate | HCID 522203 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | Ethyl 6-oxo-2-(pentafluoroethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate | HCID 86611248 | 4.2% |
반응 단계
A suspension of acrylamide (4.11 g), ethyl 4,4,5,5,5-pentafluoro-3-oxopentanoate (16.5 g) and p-toluenesulphonic acid (0.120 g) in chlorobenzene (40 mL) was sonicated for 30 minutes then heated by microwave irradiation (150 W, 120° C.) for 3 h. The reaction mixture was concentrated in vacuo and subjected to flash column chromatography (eluent 1:3 ethyl acetate/isohexane) to yield a colourless solid (0.697 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07956070B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_06 |
|---|
| ORD ID | ord-66b8a55bacc44fc0b2643845168c18ad |
|---|
| 출처 메모 | uspto-grants-2011_06 |
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