Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-Quinolinecarboxylic acid → 8-[5-(5-Methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-Quinolinecarboxylic acid | HCID 66582 | — |
| 반응물 | 5-Methyl-3-phenyl-4-isoxazolecarbohydrazide | HCID 727924 | — |
| 생성물 | 8-[5-(5-Methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazol-2-yl]-quinoline | HCID 67215409 | 49% |
반응 단계
As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (200 mg, 0.92 mmol) was converted using quinoline-8-carboxylic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate=80:20 to 50:50, 160 mg, 49%) which was obtained as a white solid. MS: m/e=355.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07956074B2 |
| 출처 데이터셋 | uspto-grants-2011_06 |
| ORD ID | ord-a6c833fb53d742f0afbf9b824562d533 |
| 출처 메모 | uspto-grants-2011_06 |