Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Methyl-3-phenylisoxazole-4-carboxylic acid → 2-(5-Methyl-3-phenyl-isoxazol-4-yl)-5-thiophen-3-yl-[1,3,4]oxadiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Methyl-3-phenylisoxazole-4-carboxylic acid | HCID 14343 | — |
| 반응물 | Thiophene-3-carbohydrazide | HCID 468648 | — |
| 생성물 | 2-(5-Methyl-3-phenyl-isoxazol-4-yl)-5-thiophen-3-yl-[1,3,4]oxadiazole | HCID 67215761 | 38% |
반응 단계
As described for example 121, 5-methyl-3-phenylisoxazole-4-carboxylic acid (357 mg, 1.76 mmol) using thiophene-3-carboxylic acid hydrazide instead of thiophene-2-carboxylic acid hydrazide was converted to the title compound (SiO2, heptane:ethyl acetate=90:10 to 60:40, 207 mg, 38%) which was obtained as a yellow semisolid. MS: m/e=310.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07956074B2 |
| 출처 데이터셋 | uspto-grants-2011_06 |
| ORD ID | ord-ceb16c521d6347aebc0d7507d1c10a10 |
| 출처 메모 | uspto-grants-2011_06 |