Methylphenidate Hydrochloride → Methylphenidate

HRID 242138

반응식

HRID 242138 반응식
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].Cl.[OH-].[NH4+]>O>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

참가 물질

4

반응물 2

HCID 9280Methylphenidate HydrochlorideHCID 14923Ammonium Hydroxide

생성물 1

HCID 4158Methylphenidate수율 95%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. About 3.39 g (96.8 mmol) ammonium hydroxide was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers dried over sodium sulfate, filtered and concentrated under reduced pressure at about 40° C. to provide 8.2 g of a clear, colorless viscous oil (95% yield). The IR spectrum of the oil was consistent with the intended product.

후처리

  1. customformed
  2. extractionThe product was extracted with three 100 mL portions of ethyl acetate
  3. dry with materialthe combined organic layers dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure at about 40° C.

출처 및 근거

ORD 기록
ord-1abda8bbfd7546549d9a2c336e58e008
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653106B2

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