Potassium Iodide → HCID 21914295, 화합물
반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10]Cl.Cl.[F:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:9][CH2:10][N:17]1[CH2:18][CH2:19][CH:14]([F:13])[CH2:15][CH2:16]1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 1-bromo-2-(2-chloroethoxy)benzene (2.35 g), 4-fluoropiperidine hydrochloride (1.54 g), potassium carbonate (4.06 g) and potassium iodide (0.83 g) in dimethylformamide (20 ml) was heated at 80° C. for 18 h. After evaporation, the residue was partitioned between ethyl acetate and water. The solvent phase was washed (brine), dried and evaporated to give an oil (1.0 g).
후처리
- customAfter evaporation
- customthe residue was partitioned between ethyl acetate and water
- washThe solvent phase was washed (brine)
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-0b689be964124d368ef1c9a5ad536f67
- 출처 데이터셋
- uspto-grants-2011_06
- 특허 번호
- US07956084B2
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