4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-morpholinoethanone

HRID 2421394노트

반응식

HRID 2421394 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:10]>C1(C)C=CC=CC=1>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[CH2:8][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 74544-Bromophenacyl bromideHCID 8083Morpholine

생성물 1

HCID 4108821-(4-Bromophenyl)-2-morpholinoethanone수율 101.3%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

Morpholine (4.35 g) in dry toluene (8 ml) was stirred during the addition of aliquots of 2-bromo-1-(4-bromophenyl)ethanone (6.95 g) in dry toluene (70 ml). The resulting precipitate was removed by filtration and the filtrate evaporated to give the product (J. Amer. Chem. Soc., 1940, 62, 2882) as a pale yellow solid (7.2 g).

후처리

  1. customThe resulting precipitate was removed by filtration
  2. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-b40b4806bb32466aa8de9b505667e52b
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07956084B2

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