Thionyl Chloride → 4-(Chloromethyl)-N-(4-fluorophenyl)-6-methylpyrimidine-2-amine
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([CH2:15]O)[CH:12]=[C:11]([CH3:17])[N:10]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:20])=O>ClCCl>[Cl:20][CH2:15][C:13]1[CH:12]=[C:11]([CH3:17])[N:10]=[C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[N:14]=1참가 물질
4
실험 절차
At 0° C., 225 mg (0.96 mmol) of the compound from example 6A and 137 mg (1.16 mmol) of thionyl chloride are initially charged in 10 ml of dichloromethane and, after warming to RT, stirred at this temperature for 24 h. The solvent is removed on a rotary evaporator and the product that remains is directly reacted further.
후처리
- customThe solvent is removed on a rotary evaporator
- customthe product that remains is directly reacted further
출처 및 근거
- ORD 기록
- ord-4600fafe061d4f6399db50d26ec7e638
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08653109B2
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