N-(2-Aminoethyl)piperidine → 3-[(2-fluoro-4-iodophenyl)amino]-N-(2-piperidin-1-ylethyl)isonicotinamide

HRID 2421691

반응식

HRID 2421691 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[N:19]1([CH2:25][CH2:26][NH2:27])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:27][CH2:26][CH2:25][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=[O:14]

참가 물질

3

반응물 2

HCID 33944N-(2-Aminoethyl)piperidineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 115183923-[(2-fluoro-4-iodophenyl)amino]-N-(2-piperidin-1-ylethyl)isonicotinamide

실험 절차

3-[(2-fluoro-4-iodophenyl)amino]-N-(2-piperidin-1-ylethyl)isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 2.5 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 4.0 mmol of 2-piperidin-1-ylethylamine. LC/MS [5.40 min; 469 (M+1)]

후처리

  1. customLC/MS [5.40 min; 469 (M+1)]

출처 및 근거

ORD 기록
ord-060fd6220bf74fe49a35e49842b4aa3e
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07956191B2

연결된 노트

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