4-Amino-1-butanol → 3-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide

HRID 2421696

반응식

HRID 2421696 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[OH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][OH:19])=[O:14]

참가 물질

3

반응물 2

HCID 258684-Amino-1-butanolHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2회

생성물 1

HCID 116116783-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide

실험 절차

3-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.5 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.63 mmol of 4-hydroxy-butylamine. LC/MS [8.42 min; 430 (M+1)]

후처리

  1. customLC/MS [8.42 min; 430 (M+1)]

출처 및 근거

ORD 기록
ord-a5e77465c8e14964926bb04696a0014b
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07956191B2

연결된 노트

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