2-Acetylpyridine-4-carbonitrile → 2-((S)-1-Hydroxy-ethyl)-isonicotinonitrile

HRID 2422186노트

반응식

HRID 2422186 반응식
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][N:11]=1)[C:7]#[N:8])(=[O:3])[CH3:2].B(Cl)([C@H]1[C@@H](C)[C@H]2C(C)(C)[C@H](C2)C1)[C@H]1[C@@H](C)[C@H]2C(C)(C)[C@H](C2)C1>>[OH:3][C@H:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][N:11]=1)[C:7]#[N:8])[CH3:2]

참가 물질

3

반응물 2

HCID 104644602-Acetylpyridine-4-carbonitrileHCID 86625794(-)-DIPCl

생성물 1

HCID 598688242-((S)-1-Hydroxy-ethyl)-isonicotinonitrile수율 78.5%

실험 절차

The title compound (1.13 g, 7.63 mmol) was prepared according to General Method E1 starting from 2-acetyl-isonicotinonitrile (1.42 g, 9.72 mmol) and (−)-DIPCl (4.67 g, 14.57 mmol).

출처 및 근거

ORD 기록
ord-915dc229d7704dcbb5ce6a0b569369df
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960395B2

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