Water → 4-phenyl-N-propyl-1,3-thiazol-2-amine

HRID 2422236노트

반응식

HRID 2422236 반응식
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[CH2:11]([NH:14][C:15]([NH2:17])=[S:16])[CH2:12][CH3:13].C([O-])(=O)C.[Na+].O>C(O)C>[C:5]1([C:3]2[N:17]=[C:15]([NH:14][CH2:11][CH2:12][CH3:13])[S:16][CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 107572-ChloroacetophenoneHCID 517045Sodium AcetateHCID 1615208Propyl-2-thiourea

생성물 1

HCID 230827804-phenyl-N-propyl-1,3-thiazol-2-amine수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-chloroacetophenone (4.45 g, 28.8 mmol) and N-propylthiourea (3.40 g, 28.8 mmol) in ethanol (50 mL) was added sodium acetate (3.07 g, 37.4 mmol), and the mixture was heated under reflux for 1.5 hrs. Water was added to the reaction mixture, and crystals were collected by filtration. The obtained crude crystals were recrystallized from diethyl ether-hexane to give the title compound (5.64 g, 92%) as colorless crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hrs
  3. filtrationwere collected by filtration
  4. customThe obtained crude crystals
  5. customwere recrystallized from diethyl ether-hexane

출처 및 근거

ORD 기록
ord-1309f79e1cdd4cc4ba387db37e1eb03d
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960369B2

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