Ethanol → N-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine hydrobromide

HRID 2422251노트

반응식

HRID 2422251 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=O.[CH2:15]([NH:18][C:19]([NH2:21])=[S:20])[CH2:16][CH3:17].C(O)C>C(OC(C)C)(C)C>[BrH:1].[CH2:15]([NH:18][C:19]1[S:20][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=2)[N:21]=1)[CH2:16][CH3:17]

참가 물질

5

반응물 3

HCID 702EthanolHCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 1615208Propyl-2-thiourea

생성물 1

HCID 23082954N-propyl-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine hydrobromide수율 70%

시약·촉매·용매 1

HCID 7914Diisopropyl Ether용매

실험 절차

A mixture of 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (5.34 g), N-propylthiourea (2.60 g) and ethanol (50 mL) was stirred for 1 hr while heating under reflux. The reaction mixture was cooled and diluted with isopropyl ether. The precipitated solid was collected by filtration, washed with isopropyl ether and dried to give the title compound (5.11 g, yield 70%) as colorless crystals.

후처리

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with isopropyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-be129a25c75a4a96a67dd0170d5191f1
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960369B2

반응 노트

불러오는 중…