Ethanol → 3-(4-Hydroxyphenyl)-propionic acid tert-butyl ester

HRID 2422262노트

반응식

HRID 2422262 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:11][CH:10]=1)C1C=CC=CC=1.C(O)C>[Pd].[C].O1CCCC1>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 15480691HCID 15480691, 화합물

생성물 1

HCID 121124243-(4-Hydroxyphenyl)-propionic acid tert-butyl ester수율 79%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of tert-butyl (2E)-3-[4-(benzyloxy)phenyl]acrylate (13.3 g, 42.8 mmol), 10% Pd carbon (1.3 g), ethanol (100 mL) and tetrahydrofuran (30 mL) was stirred under a hydrogen atmosphere for 2 hrs. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (7.5 g, yield 79%) as colorless crystals.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b4396e01e13f457b93c717e31eb81cde
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960369B2

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