3'-[4-(2-Tert-butoxycarbonylethyl)phenoxymethyl]biphenyl-2-carboxylic acid → 3'-((4-(2-Carboxyethyl)phenoxy)methyl)biphenyl-2-carboxylic acid
반응식
C([O:5][C:6]([CH2:8][CH2:9][C:10]1[CH:32]=[CH:31][C:13]([O:14][CH2:15][C:16]2[CH:17]=[C:18]([C:22]3[C:23]([C:28]([OH:30])=[O:29])=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:19]=[CH:20][CH:21]=2)=[CH:12][CH:11]=1)=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:6]([CH2:8][CH2:9][C:10]1[CH:32]=[CH:31][C:13]([O:14][CH2:15][C:16]2[CH:17]=[C:18]([C:22]3[C:23]([C:28]([OH:30])=[O:29])=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:19]=[CH:20][CH:21]=2)=[CH:12][CH:11]=1)([OH:7])=[O:5]참가 물질
3
실험 절차
3′-[4-(2-tert-Butoxycarbonylethyl)phenoxymethyl]biphenyl-2-carboxylic acid (0.15 g, 0.35 mmol) was dissolved in trifluoroacetic acid (3 mL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/2-ethyl acetate) to give the title compound (21 mg, yield 16%) as a colorless powder. MS (APCI−): 375 (M−H).