Morpholine → 4-(6-Chloropyrimidin-4-yl)morpholine
반응식
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:7]=1참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
45.0 g (302.1 mmol) 4,6-dichloropyrimidine are initially introduced into 450 ml water. 26.3 g (302.1 mmol) morpholine are added and the mixture is stirred at 90° C. for 16 h. Thereafter, it is cooled to 0° C. and the precipitate formed is filtered off. The precipitate is washed once with 50 ml water and dried in air.
후처리
- temperatureThereafter, it is cooled to 0° C.
- customthe precipitate formed
- filtrationis filtered off
- washThe precipitate is washed once with 50 ml water
- customdried in air
출처 및 근거
- ORD 기록
- ord-a91756505a5e41009dac6d88413e4ae5
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08653111B2
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