HCID 59774862, 화합물 → HCID 59774864, 화합물
반응식
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[CH:12]([C:14]1[S:15][CH:16]=[CH:17][N:18]=1)[OH:13]>ClCCl.O=[Mn]=O>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[S:15][CH:16]=[CH:17][N:18]=1)=[O:13]참가 물질
4
실험 절차
A mixture of [2-(methoxymethoxy)-4-methylphenyl](1,3-thiazol-2-yl)methanol from step 1 (3.6 g, 13.7 mmol) and MnO2 (8.28 g, 95.2 mmol) in dichloromethane was stirred at room temperature overnight, filtered, and the insoluble material washed well with boiling EtOAc. The filtrates were combined and concentrated in vacuo to afford the title compound. 1H NMR (400 MHz, acetone-d6): 8.07-8.03 (m, 2H), 7.50 (d, 1H), 7.10 (s, 1H), 6.95 (d, 1H), 5.11 (s, 2H), 3.34 (s, 3H), 2.41 (s, 3H).
후처리
- filtrationfiltered
- washthe insoluble material washed well with boiling EtOAc
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-6fb9d749276242d4bdd1ca62b42ff833
- 출처 데이터셋
- uspto-grants-2011_06
- 특허 번호
- US07960409B2
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