4-Chloro-6-hydrazinylpyrimidine → 4-Hydrazino-6-[4-(2-methoxyethyl)piperazin-1-yl]pyrimidine

HRID 242252

반응식

HRID 242252 반응식
Cl[C:2]1[CH:7]=[C:6]([NH:8][NH2:9])[N:5]=[CH:4][N:3]=1.[CH3:10][O:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>O>[NH:8]([C:6]1[CH:7]=[C:2]([N:17]2[CH2:18][CH2:19][N:14]([CH2:13][CH2:12][O:11][CH3:10])[CH2:15][CH2:16]2)[N:3]=[CH:4][N:5]=1)[NH2:9]

참가 물질

4

반응물 2

HCID 2472224-Chloro-6-hydrazinylpyrimidineHCID 27346381-(2-Methoxyethyl)piperazine2회

생성물 1

HCID 596036074-Hydrazino-6-[4-(2-methoxyethyl)piperazin-1-yl]pyrimidine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 1.0 g (6.9 mmol) of the compound from Example 7A and 1.1 g (7.6 mmol) 1-(2-methoxyethyl)piperazine in 10 ml water is stirred at 100° C. for 2 h. A further 0.9 g (6.2 mmol) 1-(2-methoxyethyl)piperazine is added and the reaction mixture is stirred further at 100° C. for 16 h. After concentration in vacuo, the residue is stirred in acetonitrile. The solid which has precipitated out is filtered off, washed first with ethanol and then with diethyl ether and dried in vacuo.

후처리

  1. stirringthe reaction mixture is stirred further at 100° C. for 16 h
  2. concentrationAfter concentration in vacuo
  3. stirringthe residue is stirred in acetonitrile
  4. customThe solid which has precipitated out
  5. filtrationis filtered off
  6. washwashed first with ethanol
  7. dry with materialwith diethyl ether and dried in vacuo

출처 및 근거

ORD 기록
ord-e264a4d9c3c84af5924e926533b54e99
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08653111B2

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