Allyltributylstannane → 7-Allyl-4-phenylquinoline-2-carbonitrile

HRID 2422567노트

반응식

HRID 2422567 반응식
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:7][C:8]([C:12]#[N:13])=[N:9]2)=[CH:4][CH:3]=1.[CH2:20]([Sn](CCCC)(CCCC)CCCC)[CH:21]=[CH2:22]>O1CCOCC1>[CH2:22]([C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:7][C:8]([C:12]#[N:13])=[N:9]2)=[CH:4][CH:3]=1)[CH:21]=[CH2:20]

참가 물질

4

반응물 2

HCID 90628AllyltributylstannaneHCID 597749247-Chloro-4-phenylquinoline-2-carbonitrile

생성물 1

HCID 597748917-Allyl-4-phenylquinoline-2-carbonitrile

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 7-chloro-4-phenylquinoline-2-carbonitrile (3.3 g, 12.5 mmol) in dioxane (120 mL) was added tetrakistriphenylphosphine (3.6 g, 3.1 mmol) and allyltributyltin (11.5 mL, 38 mmol). The mixture was refluxed for 10 h, concentrated and purified on silica gel (eluting with dichloromethane/hexanes, 3:1) to give the title compound. MS (+ESI): 271 (M+H)+.

후처리

  1. temperatureThe mixture was refluxed for 10 h
  2. concentrationconcentrated
  3. custompurified on silica gel (eluting with dichloromethane/hexanes, 3:1)

출처 및 근거

ORD 기록
ord-6e62ec91f88b452bbfd6a719e9259830
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960409B2

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